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P53 is a protein that plays an important role in the regulation of cell division and thereby offers protection to the cell against malignant transformation. This is the most well-studied and most appreciated role of p53, due to which the protein is famously known as the "guardian of the genome." It is the most studied protein in all forms of cancer research, with much of this research investigating p53's role in tumor suppression. However, research has also shown that p53 plays a role in a wide range of other cellular functions, like serving as a biomarker for environmental pollution. Even as a tumor suppressor and transcription factor, many aspects of p53 function are still obscure, and research in the field is continually attempting to shed light on these functions. This book examines and discusses the myriad roles of p53 and different aspects of its functions. Chapters examine p53 in cancer prevention, DNA repair, gene regulation, and more.
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Genetics --- Genetic Techniques --- Génétique --- Periodicals --- Technique --- Périodiques --- Genetic Techniques. --- Genetics. --- Genetics & Genomics. --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- methods --- genetics --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Genetic Structures --- Genetic Phenomena --- Genetic Counseling
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This Special Issue focuses on the current state of pharmacogenomics (PGx) and the extensive translational process, including the identification of functionally important PGx variation; the characterization of PGx haplotypes and metabolizer statuses, their clinical interpretation, clinical decision support, and the incorporation of PGx into clinical care.
pharmacogenomics --- return of results --- genetic counseling --- qualitative --- pharmacogenetics --- implementation --- pharmacogenetics service --- screening --- pre-emptive --- personalized medicine --- precision medicine --- community pharmacy --- pharmacogenomic testing --- genetic privacy --- pharmaco-economics --- polymorphisms --- pharmacogenes --- pharmacogenomic --- machine learning --- adaptation --- human evolution --- US Food and Drug Administration --- clinical actionability --- clinical translation --- chronic kidney disease --- CYP3A5 --- polymorphism --- progression --- pharmacogenomics (PGx) --- pediatrics --- best practice alerts (BPAs) --- electronic health records (EHR) --- genomic indicators --- clinical decision support (CDS) --- phenotype --- genotype --- polypharmacy --- chronic disease --- medication management --- electronic medical record --- artificial intelligence --- n/a
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Biotechnology --- Biotechnologie --- Periodicals --- Périodiques --- Biotechnology. --- Genetic Engineering. --- Genetic Techniques. --- 66.098 --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Genetics --- Genetic Counseling --- Genetic Processes --- Engineering, Genetic --- Intervention, Genetic --- Genetic Intervention --- Genetic Interventions --- Interventions, Genetic --- Cloning, Molecular --- DNA, Recombinant --- Industrial Microbiology --- Artificial Gene Fusion --- Organisms, Genetically Modified --- Animals, Genetically Modified --- Plants, Genetically Modified --- Biotechnologies --- Biological processes. Biotechnology --- methods --- Life Sciences --- Biology --- Genetic Phenomena --- 66.098 Biological processes. Biotechnology --- Genetic Engineering --- Genetic Techniques --- biotechnologie --- Chemical engineering --- Genetic engineering --- Bioengineering --- biotechnology --- applied microbiology --- biomedical research methods
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In 1953 werd door Watson en Crick de structuur van het DNA blootgelegd: dit gaf inzicht in de wijze waarop de erfelijke eigenschappen van een organisme worden 'gecodeerd' en bij elke celdeling doorgegeven. Omstreeks 1975 werd het mogelijk om DNA te 'manipuleren'. De stukjes DNA die een welbepaalde eigenschap tot stand brengen, en die men genen noemt, kan men nu isoleren, identificeren en reproduceren (klonen). In verband met de mens leidt dit samen met andere technieken tot de mogelijkheid om de oorsprong van een groot aantal erfelijke ziekten op te sporen. Door onderzoek van enkele cellen kan men de aanwezigheid van een erfelijke aanleg vaststellen zowel bij de volwassene, het kind, de foetus als bij het embryo. Deze kennis kan heel waardevol zijn, maar ze kan ook ongewenste tot zelfs dramatische gevolgen hebben. Dit boek geeft een inzicht in de mogelijkheden van dit genetisch onderzoek. Tegelijk worden ook de voornaamste ethische vragen gesteld die erdoor worden opgeroepen. (Bron: covertekst)
Human genetics --- Professional ethics. Deontology --- Human medicine --- Erfelijkheidsleer --- Ethique médicale --- Hérédité --- Medische ethiek --- Genetisch onderzoek ; ethiek --- Genetisch onderzoek ; sociale aspecten --- genetica --- erfelijke ziekten --- bio-ethiek --- 174.2 --- 17.023.33 --- 575 --- 061 Ethische problemen --- 094 Biologie --- Erfelijkheid --- Genetica --- 600.2 --- 603.1 --- aangeboren afwijkingen --- erfelijkheidsleer --- ethiek --- genetische diagnose --- genetische test --- maatschappij --- recht --- screening --- 599.2 --- aangeboren afwijkingen (congenitale afwijkingen, hartafwijkingen) --- ethiek (moraal) --- genetisch risico --- prenatale diagnose --- tests --- 010213.jpg --- 61 --- 179.7 --- Beroepsmoraal van de artsen. Medische beroepsethiek --- Génétique --- (zie ook: orthopedie, seksuele ontwikkelingsstoornissen, vaatziekten) --- (zie ook: genetisch advies) --- Conferences - Meetings --- Medical genetics --- Genetic Techniques --- Genetic Counseling --- Genetic Screening --- Moral and ethical aspects --- 174.2 Beroepsmoraal van de artsen. Medische beroepsethiek --- Clinical genetics --- Diseases --- Heredity of disease --- Medical sciences --- Pathology --- Genetic disorders --- Genetic aspects --- Hérédité --- Génétique --- Ethique médicale
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Pathology, Cellular --- Cytology --- Oncology --- Cancer --- Cytopathologie --- Cytologie --- Cancérologie --- Periodicals. --- Cytopathology --- Periodicals --- Périodiques --- Cell Transformation, Neoplastic. --- Cells --- Cytological Techniques. --- Genetic Techniques. --- Cytology. --- Oncology. --- Pathology, Cellular. --- pathology. --- Cytopathology. --- cytopathology --- pathology --- cytology --- Cellular pathology --- Pathology --- Cytodiagnosis --- Tumors --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Genetics --- Genetic Counseling --- Genetic Phenomena --- Cytologic Technics --- Cytological Technic --- Cytological Technics --- Cytological Technique --- Technic, Cytological --- Technics, Cytological --- Technique, Cytological --- Techniques, Cytological --- Cytologic Technic --- Technic, Cytologic --- Technics, Cytologic --- Cell Biology --- Neoplastic Cell Transformation --- Transformation, Neoplastic Cell --- Tumorigenic Transformation --- Neoplastic Transformation, Cell --- Cell Neoplastic Transformation --- Cell Neoplastic Transformations --- Cell Transformations, Neoplastic --- Neoplastic Cell Transformations --- Neoplastic Transformations, Cell --- Transformation, Cell Neoplastic --- Transformation, Tumorigenic --- Transformations, Cell Neoplastic --- Transformations, Neoplastic Cell --- Transformations, Tumorigenic --- Tumorigenic Transformations --- Cell Line, Transformed --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- methods --- Cell Transformation, Neoplastic --- Cytological Techniques --- Genetic Techniques --- pathology --- Cell --- Histology. Cytology --- Oncology. Neoplasms
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GENUS is an online and print peer-reviewed Journal of Population Sciences published by the University of Rome “La Sapienza” with the support of the Department of Statistical Sciences. GENUS has adopted an interdisciplinary approach to population studies. It publishes articles of “pure” demography and articles aiming to further a better knowledge of the interrelationship between demography and biological, social and economic phenomena, connected with the evolution of the population. GENUS has always tried to promote open dialogue across cultural, ideological and at times theoretical walls in the attempt to understand the complexities underlying population issues.
Demography --- Eugenics --- Genetics --- Démographie --- Eugénisme --- Génétique --- Periodicals --- Périodiques --- Eugenics. --- Genetics, Medical. --- Population. --- Demography. --- Genetics. --- Business, Economy and Management --- Economics --- Démographie --- Eugénisme --- Génétique --- Périodiques --- population --- demography --- anthropology --- population dynamics --- Genetics, Medical --- Població --- Population --- Demografia --- Homiculture --- Race improvement --- Euthenics --- Heredity --- Involuntary sterilization --- School Age Population --- School-Age Population --- Population, School Age --- Population, School-Age --- Populations --- Populations, School Age --- Populations, School-Age --- School Age Populations --- School-Age Populations --- Medical Genetics --- Anthropology, Physical --- Chromosome Disorders --- Sex Chromosome Disorders --- Genetic Diseases, Inborn --- Molecular Medicine --- Negative Eugenics --- Positive Eugenics --- Eugenics, Negative --- Eugenics, Positive --- Selective Breeding --- Genetic Counseling --- Revistes. --- Historical demography --- Social sciences --- Vital statistics --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Mutation (Biology) --- Variation (Biology) --- Periodicals. --- Demografia. --- Sociology
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Molecular biology --- Genomes --- Gene mapping --- Genomics --- Genetics --- Chromosome Mapping --- Base Sequence --- Sequence Analysis, DNA --- Genetic Techniques --- Génomes --- Cartes chromosomiques --- Génomique --- Génétique --- Periodicals --- Technique --- Périodiques --- Genomics. --- Base Sequence. --- Chromosome Mapping. --- Genetic Techniques. --- Sequence Analysis, DNA. --- Gene mapping. --- Genomes. --- Genetics & Genomics. --- Analysis, DNA Sequence --- DNA Sequence Determination --- DNA Sequence Determinations --- DNA Sequencing --- Determination, DNA Sequence --- Determinations, DNA Sequence --- Sequence Determinations, DNA --- DNA Sequence Analysis --- Sequence Determination, DNA --- Analyses, DNA Sequence --- DNA Sequence Analyses --- Sequence Analyses, DNA --- Sequencing, DNA --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Genome Mapping --- Gene Mapping --- Linkage Mapping --- Chromosome Mappings --- Gene Mappings --- Genome Mappings --- Linkage Mappings --- Mapping, Chromosome --- Mapping, Gene --- Mapping, Genome --- Mapping, Linkage --- Mappings, Chromosome --- Mappings, Gene --- Mappings, Genome --- Mappings, Linkage --- DNA Sequences --- DNA Sequence --- Nucleotide Sequence --- RNA Sequence --- Base Sequences --- Nucleotide Sequences --- RNA Sequences --- Sequence, Base --- Sequence, DNA --- Sequence, Nucleotide --- Sequence, RNA --- Sequences, Base --- Sequences, DNA --- Sequences, Nucleotide --- Sequences, RNA --- Chromosome mapping --- Genetic mapping --- Genome mapping --- Linkage mapping (Genetics) --- methods --- genomics --- genome-scale analysis --- functional genomics --- proteomics --- Haploidy --- Molecular Sequence Annotation --- Genetic Counseling --- Genetic Phenomena --- Cytogenetics --- Genetic Markers --- Cytogenetic Analysis --- Gene Order --- Synteny --- Genes --- Nucleotides --- Human Genome Project --- Genome --- Comparative Genomics --- Comparative Genomic --- Genomic, Comparative --- Genomics, Comparative --- Biotechnology --- moleculaire biologie --- biotechnologie
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Pathology, Cellular --- Cytology --- Cells --- Cytological Techniques. --- Image Processing, Computer-Assisted. --- Cytology. --- Pathology, Cellular. --- pathology. --- Histology. --- Pathology. --- Cellular pathology --- Cytopathology --- Cell biology --- Cellular biology --- Analysis, Computer-Assisted Image --- Computer-Assisted Image Analysis --- Computer-Assisted Image Processing --- Image Analysis, Computer-Assisted --- Image Reconstruction --- Computer Assisted Image Analysis --- Computer Assisted Image Processing --- Computer-Assisted Image Analyses --- Image Analyses, Computer-Assisted --- Image Analysis, Computer Assisted --- Image Processing, Computer Assisted --- Image Reconstructions --- Reconstruction, Image --- Reconstructions, Image --- Cytologic Technics --- Cytological Technic --- Cytological Technics --- Cytological Technique --- Technic, Cytological --- Technics, Cytological --- Technique, Cytological --- Techniques, Cytological --- Cytologic Technic --- Technic, Cytologic --- Technics, Cytologic --- Cell Biology --- methods --- Genetic Techniques. --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Genetics --- Genetic Counseling --- Genetic Phenomena --- Pathology --- Cytodiagnosis --- Biology --- Cytologists --- Diagnostic Imaging --- Data Compression --- Multimodal Imaging --- Cytological Techniques --- Image Processing, Computer-Assisted --- Cell --- pathology --- Biomedical Image Processing --- Digital Image Processing --- Medical Image Processing --- Image Processing, Biomedical --- Image Processing, Digital --- Image Processing, Medical --- Image Processings, Medical --- Medical Image Processings --- Processing, Biomedical Image --- Processing, Digital Image --- Processing, Medical Image --- Processings, Digital Image --- Processings, Medical Image
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